Current R&D/S&T Activities
Microglial cells are modified macrophages that protect central nervous system (CNS) from infections and other assaults to it. Its activities begin in the early weeks after birth and continue thereafter. Effect on its development and functions in early life can therefore be detrimental to neuronal activity of affected individual. Microglia acts as double edged sword. In resting state microglia helps in neuronal survival by secreting trophic factors (BDNF, IGF) and anti-inflammtory molecules (IL-10 and TGF-β). On the other hand, over activation of microglia exerts detrimental effect by releasing high amount of pro-inflammatory factors like superoxide, nitric oxide, IL-1β, IL-6 as well as TNF-α.
Environmental chemicals, such as lead, trimethyltin and diesel exhaust potentially hyperactivate microglia and induce neuronal anomalies. Our lab is focused to find out the molecular mechanisms of xenobiotic induced altered immune function of microglia.