Scientific Staff

Dr. Debabrata Ghosh
Senior Scientist
Food, Drug & Chemical Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhawan, 31, Mahatma Gandhi Marg
Lucknow - 226 001. Uttar Pradesh, India.
Email: debabrata.ghosh[at]iitr[dot]res[dot]in | Alternate Email: debabrataghosh78[at]gmail[dot]com
Tel: +91-522-2217497 | Extension: 652
Fax: 522-2628227
Area of Specialization
IMMUNOTOXICOLOGY
Current R&D/S&T Activities

RESEARCH FOCUS OF THE LAB:


Microglial cells are modified macrophages that protect central nervous system (CNS) from infections and other assaults to it. Its activities begin in the early weeks after birth and continue thereafter. Effect on its development and functions in early life can therefore be detrimental to neuronal activity of affected individual. Microglia acts as double edged sword. In resting state microglia helps in neuronal survival by secreting trophic factors (BDNF, IGF) and anti-inflammtory molecules (IL-10 and TGF-β). On the other hand, over activation of microglia exerts detrimental effect by releasing high amount of pro-inflammatory factors like superoxide, nitric oxide, IL-1β, IL-6 as well as TNF-α.