Scientific Staff

Dr Sheelendra Pratap Singh
Scientist
Regulatory Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhawan, 31, Mahatma Gandhi Marg
Lucknow - 226 001. Uttar Pradesh, India.
Email: sheelendra[at]iitr[dot]res[dot]in | Alternate Email: shilu1july[at]gmail.com
Tel: +91-522-2217497 | Extension: 667
Fax: 522-2628227
Area of Specialization
Xenobiotics Metabolism and Pharmacokinetics/Toxicokinetics
Current R&D/S&T Activities

Ø Pharmacokinetic/Toxicokinetic studies: In-vivo pharmacokinetics/toxicokinetics (bioavailability, excretion, tissue distribution and dose proportionality studies) of xenobiotics in preclinical animals using different route of administration (Oral, I.V., I.P., I.M. etc.).

Ø  Bio-analysis: Method development and validation for xenobiotics quantification in different matrices (e.g. blood, plasma, urine, tissues, water and food commodities etc.) using UPLC, LC-MS/MS and GC-MS/MS.

Ø  In-vitro metabolism: Metabolic stability, metabolite identification, CYP450/UGTs phenoytping & inhibition studies of xenobiotics using recombinant enzymes/microsomes/S9 fraction/hepatocytes as test system.

Ø  Interaction studies: Pesticide-drug, drug-drug and food-drug interaction studies using in-vitro test systems and in-vivo prediction using mathematical models.

Ø  Human pharmacokinetics prediction: Allometry scaling and in-vitro in-vivo extrapolation (IVIVE) using in-vitro and in-vivo preclinical data for predicting the pharmacokinetics/toxicokinetics in humans.

Ø  Risk assessment: Integration of species difference in metabolism & toxicokinetics, and PBPK modelling for assessing the risk of environmental toxicants/toxins exposure on human health.

ØPesticide Residue Analysis: Multi pesticide residues determination in different food commodities such as vegetables, fruits, cereals and pulses as per NABL.

Partial List of Research Publications
Awards/Honours/ Distinctions

Awards and Honors:


·   Received “YOUNG MASS SPECTROMETRIST 2014” award from Indian Society for Mass Spectrometry (ISMAS) during 29th ISMAS Symposium on Mass spectrometry (ISMAS 2015) held during Feb 2-6, 2015.

·   BMS R&D Star award for establishing “Silicon Oil Hepatocytes Uptake Assay” for studying the role of uptake transporters in xenobiotics clearance by Biocon-Bristol Myers Squibb R&D Centre, Bangalore in year 2013.

·   Team Triumph award by Biocon-Bristol Myers Squibb, Bangalore in year 2013.

·   8th Dr P.D. Sethi Annual Award 2012 for Best Paper in Pharmaceutical Analysis Sponsored by The Pharma Review. The Pharma Review and KONGPOSH Publications Pvt. Ltd. New Delhi India·   “Best Oral Presentation” award in Pharmaceutics/Pharmacology during Diamond Jubilee Celebrations organized by CSIR-CDRI, India in year 2011.

·   Selected for Novartis Biotechnology Leadership Camp “Biocamp-2011”, held during 1-3 August-2011, at Novartis, Hyderabad.

·   Travelship and local hospitality from DST for training workshop on Quantitative Analysis and Modelling in Animal Sciences during Oct. 6th-11th 2009 at Pune.

·   Awarded GATE Junior Research Fellowship by CSIR, India from Year 2007 to 2008.

·   Awarded Senior Research Fellowship by CSIR, India from Year 2008 to 2011.

·   Awarded GATE scholarship for pursuing M. Pharm by AICTE from year 2005 to 2006.


Fellowship / Membership of Professional bodies:

  • Life member of Indian Society for Mass Spectrometry
  • Life member of Indian Pharmacological Society
  • Life member of Laboratory Animal Science Association
  • Membership of Editorial Boards:
  • Pharmacognosy journal (www.phcogj.com)
  • International Journal of Drug Discovery (Bioinfo Publications)

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