Scientific Staff

Dr. Sanghamitra Bandyopadhyay
Senior Scientist
Developmental Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: sanghmitra[at]iitr[dot]res[dot]in | Alternate Email: rb12_in@yahoo.co.uk
Tel: 522-2613786 | Extension: 330
Fax: 522-2628227

Area of Specialization
Neurobiology
Current R&D/S&T Activities
Developmental and aging neurodegeneration and neurotoxicity

Summary of research

Determine/characterize cellular pathogenic mechanism of action of metals and pesticides on developing brain:

Epidemiological survey reveals that exposures to environmental metals and pesticides are critical concerns for the developing and aging Central Nervous System (CNS). With this in mind, the toxic effect of metals and metal aggregates, and pesticides on the CNS needs to be investigated. Genomics and proteomics based approaches are being used to identify the aberrations of CNS development and aging when exposed to the metals and pesticides. Both animal and cell culture studies are being performed for the purpose.

Grant-in aid Projects

  • SERB-DST-India-total 50 lakhs, “Mechanism of white matter damage by a mixture of As, Cd and Pb: Investigating the role of glutamate metabolism during CNS development”-2014-2017
  • DBT-India-total 60 lakhs; “Mechanism underlying white matter damage by metals during brain development: Role of glia-neuron interaction-2014-2017
  • DST-India-Characterisation of pathogenic mechanism of action of metal mixture on neurodevelopment-2009-2012
  • ICMR-India-Characterisation of the protective role of omega3 fatty acid against neurodevelopmental damage in metal mixture exposed rat model-2009-2013

Patent filed International patent filed:

Model of Alzheimer’s disease”, Detail in WIPO; detail Pub. No.:WO/2014/184809, International Application No.: PCT/IN2014/000330; Publication Date:20.11.2014; International Filing Date: 15.05.2014; No. 0036NF2013-CSIR

Technologies available for transfer

A “Model of Alzheimer’s disease (AD)” features a non-transgenic rat model for early AD, using a metal mixture of As, Cd and Pb, characterized by enhanced synergistic amyloidogenicity in rat cortex and hippocampus. This model can serve as a tool for (a) AD-directed drug screening, and (b) determining mechanism of AD pathogenicity. It features induction of the Abeta-mediated apoptosis and induction of inflammation in rodent brain. The invention features novel astrocyte and neuronal cellular models for AD, using a metal mixture of As, Cd and Pb, characterized by enhanced synergistic amyloidogenicity. This model can serve as a tool for (a) AD-directed drug screening in astrocytes and neurons, and (b) determining mechanism of AD pathogenicity in cells. It features induction of the Abeta-mediated apoptosis and induction of inflammation in astrocytes and neurons.
Partial List of Research Publications
Awards/Honours/Distinctions

Membership of Editorial Boards


  • Current Aging Science
  • Toxicological Sciences

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