Scientific Staff

Dr. Ravi Ram Kristipati
Scientist
Embryo Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: raviram[at]iitr[dot]res[dot]in | Alternate Email: ravi128@yahoo.com
Tel: 522-2613786 | Extension: 219
Fax: 522-2628227

Area of Specialization
Molecular Biology and Genetics, Diabetes and xenobiotics, Reproductive Toxicology
Current R&D/S&T Activities

Development of Drosophila as a model for reproductive toxicity.

Understanding the link between Diabetes and xenobiotics.

Summary of research

Development of Drosophila as a model for reproductive toxicity

Reproduction is fundamental to life and hence rapid decline in male fertility around the globe is of serious concern. Several studies attributed this decline to the exposure to environmental chemicals. In this era of industrialization, evaluation of umpteen numbers of chemicals for their potential to disrupt male reproduction is a challenging mission and accordingly requires quick and sensitive evaluation strategies. To date, mammalian models have been on the forefront of reproductive toxicity assessment for their extrapolation to humans; however, several issues limit their utility for high-throughput screening. It is pertinent to note that other in vivo models, apart from these, are relatively scarce. In this context, Drosophila with its well characterized male reproductive biology has the potential to facilitate quick reproductive toxicity screening, but this model remains underutilized. To address this issue, in the present study, we attempted to develop Drosophila based end points for reproductive toxicity assessment. Development of this system will help to provide a new, rapid, and economical Drosophila bioassay useful in the preliminary screening of chemicals for their potential to induce reproductive toxicity.

Understanding the link between Diabetes and xenobiotics

Diabetes is one of the prominent metabolic disorders in India. Approximately, 20% of the world diabetic cases are reported from India. Several studies have looked into the etiology and therapeutics of diabetes. However, the link between diabetes and xenobiotics remains neglected. In this age of industrialization and indiscriminate use of chemicals/pesticides, understanding the effects of xenobiotics on diabetes/diabetic individuals is essential.  Therefore, we are employing transgenic Drosophila to provide insights to the effects of environmental chemicals under diabetic conditions and also help to understand the consequences of chemical exposure in a diabetic scenario with potential implications for the management of diabetes.

Partial List of Research Publications
Awards/Honours/Distinctions

  • Recipient of Prof. M. S. Chennaveeraiah award for best presentation in the Eighth All India Conference on cytology and Genetics held at Bangalore.
  • Recipient of young scientist travel award from CSIR.
  • Membership of Professional bodies
  • Member, Genetics Society of America, USA.
  • Membership of Editorial Boards
  • Professional Recognition
  • Delivered a plenary lecture at the Fourth Drosophila symposium organized by Department of Zoology, University of Mysore, Mysore held on 28th and 29th March, 2008 at Mysore, Karnataka, India.
  • Invited speaker at the US/Israel Bi-national research development fund (BARD) workshop on Insect reproductive molecules: from model systems to agricultural applications, organized by University of Jerusalem, Israel, from 9-13th January, 2012.

Website / Links Details
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