Scientific Staff

Dr. Ravi Ram Kristipati
Principal Scientist
Environmental Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhawan, 31, Mahatma Gandhi Marg
Lucknow - 226 001. Uttar Pradesh, India.
Email: raviram[at]iitr[dot]res[dot]in | Alternate Email:
Tel: +91-522-2217497 | Extension: 620
Fax: 522-2628227
Areas of Specialization
Molecular Biology and Genetics, Diabetes and xenobiotics, Reproductive Toxicology
Current R&D/S&T Activities

Development of Drosophila as a model for reproductive toxicity.

Development of Drosophila based model useful for the assessment of endocrine disruption potential of xenobiotics

Understanding the link between Diabetes and xenobiotics.

Summary of research

Development of Drosophila as a model for reproductive toxicity

Reproduction is fundamental to life and hence rapid decline in male fertility around the globe is of serious concern. Several studies attributed this decline to the exposure to environmental chemicals. In this era of industrialization, evaluation of umpteen numbers of chemicals for their potential to disrupt male reproduction is a challenging mission and accordingly requires quick and sensitive evaluation strategies. To date, mammalian models have been on the forefront of reproductive toxicity assessment for their extrapolation to humans; however, several issues limit their utility for high-throughput screening. It is pertinent to note that other in vivo models, apart from these, are relatively scarce. In this context, Drosophila with its well characterized male reproductive biology has the potential to facilitate quick reproductive toxicity screening, but this model remains underutilized. To address this issue, in the present study, we attempted to develop Drosophila based end points for reproductive toxicity assessment. Development of this system will help to provide a new, rapid, and economical Drosophila bioassay useful in the preliminary screening of chemicals for their potential to induce reproductive toxicity.

Understanding the link between Diabetes and xenobiotics

Diabetes is one of the prominent metabolic disorders in India. Approximately, 20% of the world diabetic cases are reported from India. Several studies have looked into the etiology and therapeutics of diabetes. However, the link between diabetes and xenobiotics remains neglected. In this age of industrialization and indiscriminate use of chemicals/pesticides, understanding the effects of xenobiotics on diabetes/diabetic individuals is essential.  Therefore, we are employing transgenic Drosophila to provide insights to the effects of environmental chemicals under diabetic conditions and also help to understand the consequences of chemical exposure in a diabetic scenario with potential implications for the management of diabetes.

Partial List of Research Publications
Awards/Honours/ Distinctions

  • Recipient of Prof. M. S. Chennaveeraiah award for best presentation in the Eighth All India Conference on cytology and Genetics held at Bangalore.
  • Recipient of young scientist travel award from CSIR.
  • Membership of Professional bodies
  • Member, Genetics Society of America, USA.
  • Professional Recognition
  • Delivered a plenary lecture at the Fourth Drosophila symposium organized by Department of Zoology, University of Mysore, Mysore held on 28th and 29th March, 2008 at Mysore, Karnataka, India.
  • Invited speaker at the US/Israel Bi-national research development fund (BARD) workshop on Insect reproductive molecules: from model systems to agricultural applications, organized by University of Jerusalem, Israel, from 9-13th January, 2012.
  • Invited speaker at the International conference on Insect Reproductive molecules, organized by Cornell University, from 07-09th July, 2014 at Ithaca, USA.
  • Invited speaker at the International Conference on Challenges in Environmental Science & Engineering (CESE-2017), organized by Yunnan Minzu University, from 11-15th Nov, 2017 at Kunming, China.
  • Invited speaker at Insect Reproductive Molecules meeting 2018 (IRM-2018) organized by University of Groningen in Groningen, The Netherlands
  •  Recipient of SERB travel grant 2018

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