Scientific Staff

Dr. Mahendra Pratap Singh
Principal Scientist
Toxicogenomics & Predictive Toxicology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: mpsingh[at]iitr[dot]res[dot]in | Alternate Email: singhmahendrapratap@rediffmail.com
Tel: 522-2613786 | Extension: 337
Fax: 522-2628227
Area of Specialization
Toxicogenomics & Predictive Toxicology Biochemical Pharmacology
Current R&D/S&T Activities

Molecular mechanism of Parkinsons disease and development of molecular fingerprints Parkinsons disease (PD), a progressive multi-factorial neurodegenerative disorder, is contributed by combination of age, genetic and environmental factors. Despite of extensive researches, complete mechanism and early diagnosis of PD are not yet completely established. Genomics and proteomics based approaches are used to understand the molecular mechanism of PD, develop signature fingerprints/biomarkers for an early diagnosis and mechanism involved in neuroprotection. Studies are being done to develop signature fingerprints/biomarkers, elucidate the mechanism of pesticide induced PD phenotype and nicotine and caffeine induced neuroprotection. Development of biomarkers of toxic responses and assessment of contribution of genetic polymorphism in toxicant induced diseases In this program the differential display of qualitative and quantitative changes in thousands of genes/proteins present in unexposed and toxicant exposed tissues are being studied using transcription profiling/proteomics. Involvement of nitric oxide and toxicant responsive genes in chemical induced cytotoxicity and transcription profiling in toxicant exposed animal tissues in presence or absence of protective agents are being done for understanding the mechanism of toxicity and its reversal. Additionally, single nucleotide polymorphism (SNP) in toxicant responsive genes, tumor suppressor genes and genes involved in signal transduction are being studied for establishing associations of single nucleotide polymorphism with susceptibility of toxicant induced diseases.

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