Scientific Staff

Dr. C. Kesavchandran
Senior Scientist
Epidemiology
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: ckchandran[at]iitr[dot]res[dot]in | Alternate Email: kesavachandran@rediffmail.com
Tel: 522-2613786 | Extension: 111
Fax: 522-2628227

Area of Specialization
Environmental Epidemiology, Occupational Health
Current R&D/S&T Activities

  • Exposure assessment of particulate matter pollutants, toxicants in ambient/ indoor air; its respiratory health risks in general and occupationally exposed population.
  • Pesticide exposure and its sub-clinical, clinical and genetic effects in agrarian communities based on multi-centric studies and pre-post seasonal studies.
  • Meta-analysis for evidence based environmental epidemiological issues

Summary of research

  • Blacksmith Institute’s (Switzerland) world’s worst pollution problems report 2010 identified pesticides as one of the top six toxic threats; our paper in Rev Environ Contamin Toxicol 2009:200: 33-52  was one of the basis of this selection [Cited in the report, page 51].
  • A new overweight ‘cut off’ for Body Mass Index (24.5 kg/m2) in North Indian population was predicted based on body fat % and morbid conditions studied in one thousand one hundred and eleven subjects using ROC curve analysis (Ind J Med Res, 2012; 135:72-77). This information will be useful in the future environmental/ occupational/ public health programs.
  • Our study observed that the risk of cholinesterase inhibition is greater in tractor-mounted than in knapsack pesticide sprayers. To reduce the occupational exposure in pesticide sprayers, the study suggest the redesign of spraying equipment with minimum exposure may be developed (Occup Med 2011, 10.1093/occmed/kqr064).
  • The first report regarding poor ambient air quality and its effects on lung function decline in residents living adjacent to Special Economic Zones in India during developmental phase (Clean Tech Environ Policy 2010, 10.1007/s10098-010-0337-x).
  • Prolonged exposure to mixture of pesticides, ergonomic factors and decline in cholinesterase activity (AChE and BChE) are considered as factors for decline in nerve conduction velocity in pesticide sprayers. The MNCV and SNCV can be utilised as new clinical biomarker for pesticide exposure (Toxicol Environ Chem 2011; 93:1:188-196).
  • Haematological variations well correlate with exposure period, lower ChE activity and presence of OC pesticides in blood in pesticide sprayers. (Toxicol Environ Chem 2010; 92:10:188-196).
  • First report on the increased concentration levels of PM1, PM2.5 and its effects on reduction in FEV1, PEFR among residents in NCR, India (Environ Monitor Assess, DOI: 10.1007/s10661-012-2630-0) after Ministry of Environment and Forest (MOEF) implemented the revised permissible NAAQS standard for PM2.5 in the residential areas (The Gazette of India, Part III Section 4, Nov 18, 2009, Pg 1-4).
  • Chromium exposure in general population in rural areas near Kanpur and its health outcomes due to dumping of chromium VI in the outskirts of leather tannery industries was reported by our group (PLOS One, DOI: 10.1371/journal.pone.0047).
  • Prevalence of cataract due to radiation exposure of interventional cardiologists and staff  was observed in a global comparison study based on systematic review and meta-analysis (Rev Environ Contamin Toxicol, DOI 10.1007/978-1-4614-4717-7_2).Hands are more exposed to radiation in interventional orthopedic surgeon and staff at work place compared to thyroid and eyes, eventhough the radiation dose are within the recommended limits (work done at UKE, Hamburg; Eur J Med Res, DOI:10.1186/2047-783X-17-28).
  • Frequency of thyroid dysfunctions as side effects in IFN treated HCV patients was analyzed based on global comparison (work done at UKE, Hamburg; PLOS ONE, DOI: 10.1371/journal.pone.0055364). Variations in IFN dosage, treatment duration of IFN, definition/criteria followed in each study for thyroid dysfunction and irregular thyroid function testing during treatment in different studies influence the outcome of a single study.

 


Partial List of Research Publications
Awards/Honours/Distinctions

  • Berufsgenossenschaft fur Gesundheitsdienst und Wohlfahrtspflege, Hamburg (BGW) grant for Guest Scientist position at University Medical Centre, Eppendorf, Hamburg (2011-2013), availed for 2011-2012.
  • Nominated Board of advisor, Journal of Indian Society of Toxicology, AIMS, Cochin, India (2008-2012).
  • Technical Advisor, University Grants Commission Project, Providence college, Coonoor, India.
  • Expert in database of Indian Biomedical Scientists by Indian Council of Medical Research.
  • Expert in database of Environmental professionals by Ministry of Environment and Forest, Government of India.
  • Three published papers selected as most popular article of Ind J Occup Env Med
  • Chairman of a session, International Conference on Health, Occupation and Environment in unorganized sector, Nov 1-3, 2004, ITRC, Lucknow, India
  • Chairman of a session, Endemic and endangered species of the Nilgiris, Govt. Arts College, Nilgiris, Aug 22, 2008.
  • Member, Task-Force for Environmental Contaminants: Screening Technologies and Effect on Human Health (Network project (NWP-17) of CSIR), Nodal Lab: IITR, Lucknow (2007-2012). 
  • Speaker for scientific presentation, 41st Research Council meeting, IITR, Lucknow Oct 2008.
  • Invited Speaker, Environmental science section, Indian Science congress, SRM university, Chennai, Jan 5, 2011
  • Resource guidance, UGC Major project: Project Name: Evaluation of the protective effect of Omega 3 fatty acids against Arsenic trioxide induced cardiac toxicity. PI: Dr R Harikumaran Nair, Assistant Professor, School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, Period: 2011-2014.
  • Invited Participant, 6th Hanseatic India Colloquium “New Medicine in a Changing World” October 21, 2011, Hamburg, Germany Sponsored by Govt of India and Germany.
  • Nominated as member for future capacity building workshop on evidence based medicine (EBM) sponsored by Indian council of medical Research, Govt. of India, 25-26 Sept 2012, New Delhi.
  • Article: Frequency of Thyroid Dysfunctions during Interferon Alpha Treatment of Single and Combination Therapy in Hepatitis C Virus-Infected Patients: A Systematic Review Based Analysis., Plos One, 2013 (DOI: 10.3410/f.717985101.793472622), has been selected for F1000Prime. It was recommended as being of special significance in its field by Faculty Member-Philip Rosenthal, University of California and The editorial team of the F1000 Gastroenterology & Hepatology.
  • Fellowship / Membership of Professional bodies
  • Life member, Indian Science Congress Association, Kolkata, India
  • Life member, Association of Physiology & Pharmacology India, All India Institute of   Medical Sciences, New Delhi, India
  • Life member, Indian Association of Toxicology, Amrita Institute of Medical Sciences, Cochin, India
  • Membership of Editorial Boards
  • Nominated Board of advisor, Journal of Indian Society of Toxicology, AIMS, Cochin, India (2008-2012).
  • Professional Recognition
  • Reviewer, Physiology section, Journal of Post graduate Medicine, India.
  • Reviewer, Preventive Medicine, Elsevier Publications, USA.
  • Reviewer, Food and Chemical Toxicology, Elsevier Publications, USA.
  • Reviewer, Toxicology International, STOX, India.
  • Reviewer, Journal of Clinical Pathology and Forensic Medicine (JCPFM), Thailand.
  • Reviewer, Cutaneous and Ocular Toxicology, Informa Healthcare, USA
  • Reviewer, Science of the Total Environment, Elsevier Publications, USA.
  • Reviewer, Toxicology and Industrial Health, Sage Publications, USA.
  • Reviewer, Journal of Occupational Medicine and Toxicology, BMC, U.K.
  • Reviewer, Reviews in Environmental Contamination Toxicology, Springer, USA.

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