Current R&D/S&T Activities
- Evaluation of adverse effects of engineered nano-materials in soil nematode, Caenorhabditis elegans: A genomic and proteomic approach.
- Evaluation of organismal sensitivity to environmental agents induced toxicity: A Comparative eco-toxicogenomics approach.
Summary of research
Evaluation of adverse effects of engineered nano-materials in soil nematode, Caenorhabditis elegans: A genomic and proteomic approach
Nanomaterials (NMs) possess infinite market potential globally and hence are manufactured, utilized and disposed into environment in huge quantities. Many of these nano-wastes are non-biodegradable and hence they cause nano-pollution. Since the physico-chemical properties of NMs are size related, even a slight change in size would yield completely new/different physical/chemical properties and the consequence of the same on health and environment is poorly understood. Therefore, in this era of nano-science and nano-technology both at national as well as global level, it is crucial to predict possible size-related nanomaterial risks on health and environment. In this regard we employ ASTM approved Caenorhabditis elegans, an alternate to animal model, to investigate the ecotoxicological effects of nano-material exposures. The study aims to identify molecular signatures of size related nanotoxicity, useful for future toxicological screening of nanomaterials.
Evaluation of organismal sensitivity to environmental agents induced toxicity: A Comparative eco-toxicogenomics approach
Global urbanization/industrialization has increased the exposure threats to various environment agents. However susceptibility of an organism to environmental agents is depicted by its genetic constitution. Therefore, evaluation of the adverse effects of environmental agents involving organisms from different ecological strata would help in understanding the genetic/biochemical basis of organismal sensitivity to environmental agents induced toxicity. In this regard the susceptibility of C. elegans to synthetic pyrethroids is being analysed. (This project is being carried out in parallel in Drosophila in collaboration with Dr. D Kar Chowdhrui and Dr. Ravi Ram).