Scientific Staff

Dr Amit Kumar
Senior Scientist
System Toxicology & Health Risk Assessment
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: amit.kumar[at]iitr[dot]res[dot]in | Alternate Email: NA
Tel: +91-522-2217497 | Extension: 710
Fax: 522-2628227
Area of Specialization
Genome Integrity, DNA Repair, Nuclear Architecture, Cell Plasticity, Genetic Toxicology
Current R&D/S&T Activities
Current research 
Genomic integrity is essential for accurate gene expression and epigenetic inheritance. Environmental, exogenous/endogenous agents continuously damage human genome. The toxic effects of these factors induce lesions in DNA causing mutations and deletions in chromosomes resulting in genome instability that have immediate effect on cell function as well as long-term consequences. To counteract the deleterious effects of DNA lesions, cells have developed sophisticated genome caretaking mechanisms to overcome DNA damage through specialized network of DNA repair pathways regulated by DNA damage checkpoint proteins. These apical DNA damage checkpoint proteins regulate integrity of chromosomes through coordination of the cell cycle progression with DNA repair, DNA replication and recombination processes through induction of the DNA damage response (DDR). Improper repair of DSBs can lead to various developmental defects and become genesis of many modern diseases. Overall, we aim to study how cells respond to DNA damage and in addition understanding the mechanistic insights of how are distinct cellular processes coordinated in time for full restoration of genome integrity. 
Partial List of Research Publications
Awards/Honours/ Distinctions
  1. Wellcome-DBT India alliance (2017 – 2022), Intermediate Fellow.
  2. EMBO-Short-term fellowship (2013).
  3. Marie Curie Fellow (2012 – 2014), European Union.
  4. EMBO Fellow (2012 – 2014), EMBL,  Germany.

Editorial Board 
Mutagenesis Journal (Oxford University Press, U.K.)    

Publications Link:
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