Scientific Staff

Professor Alok Dhawan
Director
Director's Office
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg,
Lucknow - 226 001. Uttar Pradesh, India
Email: alokdhawan[at]iitr[dot]res[dot]in | Alternate Email: dhawanalok[at]hotmail[dot]com
Tel: 522-2613786 | Extension: 633
Fax: 522-2628227
Area of Specialization
Alternate to animal models in toxicology, Genetic toxicology, Nanomaterial toxicology, In silico toxicology
Current R&D/S&T Activities

MULTIPLE MOUSE ORGAN GENOTOXICITY
  • International Journal of Cancer 112 (5): 890-895, 2004.
  • Food and Chemical Toxicology 43(1):147-153, 2005.
  • International Journal of Cancer 117: 709-717, 2005. 
  • Cancer Letters 244: 109-118, 2006. 
  • Molecular Carcinogenesis 45 (11): 805-813, 2006.
  • Mutation Research, Genetic Toxicology and Environmental Mutagenesis 607 (2):176-183, 2006.
  • Toxicology and Applied Pharmacology 234(2):192-201, 2009 (Cover page article).

 NANOMATERIAL TOXICOLOGY

 Nanomaterials have recently gained importance due to their widespread use worldwide in consumer products including drugs. At IITR, I established nanomaterial toxicology and published on genotoxicity of nanoparticles [carbon C60 fullerenes] in human lymphocytes. Our data has also demonstrated the in vitro cytotoxicity and genotoxicity of ZnO and TiO2 in human skin epithelial cells and unraveled the mechanism of toxicity. We also developed a novel method to detect the uptake of nanoparticles in bacteria for assessing ecotoxicity of engineered nanomaterials. I was also instrumental in developing a Guidance Document for Safe Handling of Nanomaterials in the Laboratory.

  • Environmental Science and Technology, 40(23): 7394-7401, 2006.
  • Journal of Materials Chemistry, 18: 2601-2606, 2008.
  • Nanotoxicology, 3(1), 1-9, 2009.
  • Toxicology Letters, 185: 211-218, 2009. 
  • New Journal of Chemistry, 24: 294-301, 2010.
  • Journal of Materials Chemistry, 20: 4949 – 4954, 2010.
  • Analytical and Bioanalytical Chemistry, 398:589-605, 2010. 
  • International Journal of Green Nanotechnology: Physics and Chemistry,2: 80–99,  2010.
  • Toxicology in vitro, 25:231-241, 2011.
  • Journal of Biomedical Nanotechnology, 7(1): 177-178, 2011.
  • Journal of Biomedical Nanotechnology, 7(1): 218-224, 2011.
  • Chemosphere, 83 (8): 1124-1132, 2011.
  • Cytometry Part A, 79A: 707-712, 2011.
  • Free Radical Biology and Medicine, 51: 1872–1881, 2011.
  • Mutation Research, 745(1-2): 84-91, 2012.
  • Apoptosis, 17(8): 852-870, 2012.
  • RSC Advances, 2: 1387-1403, 2012.
  • Nanotoxicology, 7(1): 48-60, 2013.
  • Food and Chemical Toxicology, 57: 352-361, 2013.
  • Carbon, 62: 222–232, 2013.
  • Langmuir, 29(46): 14230-14238, 2013.
  • In Nanoscience and Technology for Mankind. Ed. Professor Ashok Misra and Professor Jayesh Bellare. Publisher, Humana Press, pp 160-194 (2014).
  • Nanotoxicology. 8(3), 233-278, 2014. 
  • Mutation Research Reviews.  759:27-39, 2014.
  • Biomedicine & Pharmacotherapy Biomed Pharmacother. 68(1): 59-64, 2014.
  • Nanomedicine. 9(9): 1423-1434, 2014.
  • Journal of Translational Toxicology. 1: 28-39, 2014. [Article on Cover Page]
  • Journal of Translational Toxicology. 1: 1-6, 2014.
  • Environmental and Molecular Mutagenesis. 56(2): 204-217, 2015.
  •  Journal of Molecular Graphics and Modelling. 61:175-185, 2015.
  • Mutagenesis. 30(2): 237-245, 2015.
  • Journal of Applied Toxicology. 35(10):1179-1188, 2015. 
  • Current Drug Metabolism. 16, 645-661, 2015.
  • Aquananotechnology: Global Prospects. Ed: Professor David E. Reisner and Professor T. Pradeep. Publisher: CRC Press, Taylor and Francis Group, (2015). Pages: 97-104. 
  • Food and Chemical Toxicology. 85:61-70, 2015.

 IN SILICO TOXICOLOGY

 In silico toxicology has now gained worldwide acceptance for screening toxicants and understanding the mechanism of action of drugs and chemicals. At IITR, I established the in silico facility utilized it to unravel the mechanism of genotoxicity of benzene and its metabolites especially with reference to the inhibition of human topoisomerase enzyme as well as to understand the factors contributing to the genotoxicity in petrol pump workers.  More recently our studies on molecular modeling and simulation have revealed that fullerenes bind at the ATP binding site of human topoisomerase-II alpha and inhibit the enzyme activity. We have also shown that carbon based nanomaterials such as graphene and its derivatives can bind and stabilize intracellular proteins.

  • Environmental and Molecular Mutagenesis, 49:695-707, 2008.
  • Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis, 661:57–70, 2009. 
  • Journal of Biomedical Nanotechnology, 7 (1):177-178, 2011 (Cover page article).
  • Toxicological Sciences, 126(2): 372–390, 2012 (Cover page article).
  • Carbon, 62: 222–232, 2013.
  • Langmuir, 29(46): 14230-14238, 2013.
  • Journal of Molecular Graphics and Modelling. 61:175-185, 2015.

Partial List of Research Publications
Awards/Honours/ Distinctions

2015    Institution Development Award, Ahmedabad University for ILS

2014    Advisor, Knowledge Consortium of Gujarat, Ministry of Education, Government of Gujarat

2013    Fellow, Gujarat Academy of Sciences, India

2012    Fellow, The Academy of Toxicological Sciences, USA

2011    Vigyan Ratna Award by the Council of Science and Technology, UP, Government of Uttar Pradesh   

2010    Top Reviewer, Mutation Research (GTEM), Elsevier Publishers.

2010    STOX/ASAW Surajben Jethalal Thakar Prakruti Mandir Gold Medal

2009    Fellow, The National Academy of Sciences, India

2009    Fellow, The Academy of Environmental Biology, India

2008    Lecture Award in the field of Toxicology 2008, The National Academy of Sciences, India.

2008    Invited to contribute a chapter in the General and Applied Toxicology book

2008    UKIERI-DST Standard Research Award on Cellular Fate of Novel Nanomaterials for Therapeutics and Consumer Products in collaboration with Prof. Diana Anderson, University of Bradford.         

2007    UK-India Education and Research Initiative (UKIERI) Travel Award for formulation of an Indo-UK collaborative project on nanomaterial toxicology from January 15 - 25, 2007 (with Prof. Diana Anderson).

2006    Our research findings were made the reference values for DNA damage by comet assay in lymphocytes of the Indian population (Mutation Research Reviews 612: 84-104, 2006).

2005    Environmental Mutagen Society – Travel Award to present a paper at the 9th International Conference on Environmental Mutagens, and the 36th Annual Meeting of the Environmental Mutagen Society at San Francisco, USA from September 3-8, 2005.

2005    Shakuntala Amir Chand Prize 2002, of ICMR in the field of Biomedical Research

2005    Elected, Member, National Academy of Medical Sciences, India

2004    Fellow, Society of Toxicology (India)

2003    Moderator of NIH Listserv on Comet Assay hosted on the website www.cometassay.com

2000    BOYSCAST Fellowship 2000, in the field of Molecular Epidemiology from Department of Science & Technology, Govt. of India.

1999    CSIR Young Scientist Award 1999 in the field of Biological Sciences

1996    Tulsabai Somani Educational Trust Award 1996, for the best paper presented at the XIV Annual Conference of Indian Academy of Neurosciences.

1994    Visiting Scientist under bilateral exchange programme between Indian National Science Academy (India) – The Royal Society (U.K.) to work at BIBRA Toxicology International, Surrey, U.K. (with Prof. Diana             Anderson)

1994    Congress Award by IUPHAR to present a paper in the XIIth International Congress of Pharmacology held at Montreal, Canada from July 24 29, 1994.

1993    INSA Medal For Young Scientist 1993 in the field of Medical Sciences.

1990    Fellowship by IUPHAR to present a paper in the XI International Congress of Pharmacology held at Amsterdam, The Netherlands.

1990    Research Fellow Award of Industrial Toxicology Research Centre, Lucknow, for the year 1989-1990.

               

Membership of Professional Bodies

 

  • Member, Scientific Advisory Committee (SAC) of National Institute for Research in Environmental Health (NIRECH), Bhopal, 2016-
  • Member, Research Council, CSIR-National Environmental Engineering Research Institute, Nagpur, 2015-
  • Member, Research Council, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow, 2015-
  • Member, Research Council, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 2015-
  • Scientific Advisory Committee, National Institute of Occupational Health (ICMR), Ahmedabad, 2015-
  • Chairman, CSIR-Task Force on Nanomaterials: Applications Impact on Safety, Health and Enviroment (NanoSHE), 2015-
  • Chairman, CSIR-Task Force on Integrated NextGen Approaches in Health, Disease and Environmental Toxicity (INDEPTH), 2015-
  • Advisor, Knowledge Consortium of Gujarat, Government of Gujarat, 2014-
  • Member, RCGM, Department of Biotechnology, Government of India, 2014-
  • Member, Expert Group on Nanosafety Guidelines, ICMR, 2013-
  • Member, DBT-CREST Awards Committee, 2011- .
  • Member, Working Group on Nanotechnology, Bureau of Indian Standards, 2009-2012
  • Member, Task Force on Nanomedicine, ICMR 2009 –
  • Member, Project Review Committee, Department of Biotechnology, 2012-
  • Secretary, The National Academy of Sciences, India – Lucknow Chapter, 2009 – 2011
  • Founder & Chairman, Ahmedabad Chapter, The National Academy of Sciences, India, 2012-
  • Member, Executive Committee, The National Academy of Sciences (India) – Lucknow Chapter: 2007 – 2009
  • Member, Bioinformatics Centre, Lucknow, 2001-
  • Member, Biotechnology City, Lucknow, 2002-
  • Member, Biotech Park, Lucknow 2002-
  • Member, CSIR Task Force on Animal Models and Animal Substitute Technologies 2002-2007.
  • Member, CSIR Task Force on Validation of Identified Screening Models and Development of New Alternative Models for Evaluation of New Drug Entities 2007-2012.
  • Member, CSIR Task Force on Nanomaterials and Nanodevices in Health and Disease 2007-2012.
  • Member, Product Selection Committee, National Aids Research Institute, Pune 2006-2007
  • Member, Scientific Advisory Committee, AquaBiochip Genomics Pvt. Limited, Lucknow 2007-2008.
  • Member, Institutional Bio-Safety Committee, Gennova Biopharmaceuticals, Pune 2007-2013.
  • Member, Doctoral Committee, Department of Toxicology; Faculty of Engineering & Interdisciplinary Sciences, Jamia Hamdard, 2011-

Fellowship/Memberships of Scientific Societies:

 

  • Fellow - Academy of Toxicological Sciences, USA
  • Fellow - The National Academy of Sciences, India
  • Founder Fellow- Indian Nanoscience Society
  • Fellow - Gujarat Science Academy
  • Fellow - Society of Toxicology (India)
  • Fellow - Academy of Science and Animal Welfare
  • Fellow - The Academy of Environmental Biology
  • Vice President - Environmental Mutagen Society of India
  • Elected Member - National Academy of Medical Sciences, India
  • Member - United Kingdom Environmental Mutagen Society, UK
  • Member - Asian Association of Environmental Mutagen Societies, Japan
  • Member, Executive Council, The National Academy of Sciences, India
  • Elected Member – The National Academy of Sciences (India)
  • Member – Academy of Environmental Biologists
  • Member – Environmental Mutagen Society of India
  • Member – Electron Microscopy Society of India
  • Member – Indian Academy of Neurosciences
  • Member – Indian Pharmacological Society

Professional Recognition

 

  • 2011    Vigyan Ratna, Council of Science & Technology, Government of UP, India
  • 2010    Gold Medal, Society of Toxicology, India
  • 2008    Lecture Award in the field of Toxicology 2008, The National Academy of Sciences, India.
  • 2005    Shakuntala Amir Chand Prize 2002, of the Indian Council of Medical Research in the field of Biomedical Research.
  • 2000    BOYSCAST Fellowship 2000, in the field of Molecular Epidemiology from Department of Science & Technology, Govt. of India to work in the UK in the  University of Guildford, Wales and Bradford.
  • 1999    CSIR Young Scientist Award 1999 in the field of Biological Sciences awarded by Council of Scientific and Industrial Research, New Delhi.
  • 1994    Visiting Scientist under bilateral exchange programme: Indian National Science Academy (India) The Royal Society (U.K.) to work at BIBRA Toxicology  International, Surrey, U.K.
  • 1993    INSA Medal For Young Scientist 1993 in the field of Medical Sciences awarded by the Indian National Science Academy, New Delhi.

Member of Editorial Board

 

  • Editor of a book entitled “Genotoxicity Assessment: Methods and Protocols” Edited by Professor Alok Dhawan and Dr. Mahima Bajpayee for Humana Press under its much acclaimed Methods in Molecular Biology series. Volume 1044, August, 2013. http://www.springer.com/biomed/pharmacology+%26+toxicology/book/978-1-62703-528-6
  • Guest Editor, Special Issue on Nanotechnology, Proceedings of National Academy of Sciences India: Section B Biological Sciences, Volume 82 Supplement 1, 2012.
  • Editor-in-Chief, Journal of Translational Toxicology published by American Scientific Publishers, USA (2012-).
  • Editor-in-Chief, Journal of Bionanoscience published by American Scientific Publishers, USA (2010-11).
  • Associate Guest Editor of a special issue of Teratogenesis, Carcinogenesis and Mutagenesis Journal (Supplement 1, 2003) published by Wiley-Liss, Inc, U.K.
  • Guest Editor of a Special Issue of Nanotoxicology journal (Volume 2 Supplement 1, February 2008) published by Informa Healthcare on behalf of the Taylor & Francis Group.
  • Guest Editor of Nanotoxicology Journal (Volume 3 Issue 1, January 2009) published by Informa Healthcare on behalf of the Taylor & Francis Group.
  • Editor of a book entitled the Comet Assay in Toxicology, by Prof. Alok Dhawan and Prof. Diana Anderson for the Royal Society of Chemistry, London, under its series on Issues in Toxicology ISBN: 978-0-85404-199-2, 2009.
  • Guest Editor of Journal of Biomedical Nanotechnology (Volume 7, Number 1, February 2011) published by American Scientific Publishers, USA.
  • Series Editor: Methods in Toxicology and Pharmacology, Elsevier, UK
  • Senior Editor: Mutagenesis 2014-
  • Member: Mutation Research Reviews: 2011-14
  • Member: Proceedings of National Academy of Sciences, India: Section B Biological Sciences: 2012-
  • Member: Nanotoxicology: 2013
  • Member: Xenobiotica: 2013
  • Member: Mutation Research – Genetic Toxicology & Environmental Mutagenesis: 2011-2014
  • Editorial Advisor: to the Issues in Toxicology Books Series, The Royal Society of Chemistry, U.K., 2013-14

Choose Theme Options
Set Font Size Predefined Color Skins